Overview
Palmitoyl dipeptide-6 is sold as a cosmetic peptide active. It is catalogued here for completeness, with the clear statement that it is among the least verifiable entries in this collection.
No PubChem record could be matched to this name in this session. That means no confirmed molecular formula, no molecular weight, no CAS number, and therefore no public reference against which purchased material can be checked. This contrasts directly with palmitoyl tripeptide-1 (CAS 147732-56-7), palmitoyl tripeptide-5 (CAS 623172-55-4), pentapeptide-3 (CAS 135679-88-8) and tripeptide-29 (CAS 2239-67-0), each of which resolves cleanly.
The INCI dipeptide numbering system is a naming convention, not a structural description: 'dipeptide-6' tells you the ingredient contains two amino acids and was assigned the number six, and nothing about which two. Two products bearing the same INCI name are verifiable as the same substance only through the supplier, not through the name.
What can be said generally is that the palmitoyl prefix indicates fatty acid conjugation for skin partitioning, the same delivery strategy used across this category.
The limiting factor for every topical peptide is delivery. Peptides are hydrophilic and relatively large, while the stratum corneum is a lipophilic barrier built to exclude exactly such molecules. A peptide that performs well in a fibroblast culture has not thereby been shown to reach fibroblasts through intact skin. Reviews of cosmeceutical peptides identify this permeability gap — not receptor pharmacology — as the principal open problem, and note that formulation strategies such as oil-in-water and water-in-oil-in-water emulsions are used to try to close it with uncertain success.
What the evidence shows
Separated by study type- HumanClinical trials and human studies
- No controlled clinical trials isolating this ingredient were located.
- AnimalRodent and other animal models
- None located.
- In vitroCell and tissue studies
- None located.
Key studies & findings
1 study- 1
No PubChem record was retrievable for palmitoyl dipeptide-6 in this session, so no molecular formula, molecular weight or CAS number could be confirmed — unlike the other palmitoylated cosmetic peptides catalogued here, which all resolve to registry entries.
Benefits & effects
No benefit data has been compiled for this entry yet.
Side effects & safety
Safety noteCosmetic ingredient used topically in finished formulations. Injecting cosmetic peptides is not an established route, has no supporting safety data, and is not a use these ingredients were characterised for.
Recorded in the cited literature No confirmed chemical identity — material cannot be verified against a public reference · No efficacy or safety literature located.
No specific adverse events have been compiled for this entry. Absence of data is not evidence of safety.
Limitations & open questions
No confirmable chemical identity, no CAS number, no molecular formula, and no located efficacy literature. The INCI name indicates only that the ingredient is a palmitoylated two-residue peptide assigned that number; it does not specify which residues. Material purchased under this name cannot be verified against any public reference.
Pharmacology
No chemical identity could be confirmed under this name. Molecular formula, weight and CAS number are therefore not stated here.
Frequently asked questions
What amino acids are in palmitoyl dipeptide-6?
Not confirmable from any public source located. The INCI numbering says only that it is a two-residue peptide assigned the number six; it does not identify the residues.
Why is that a problem?
Because there is no public reference to check purchased material against. Other palmitoylated cosmetic peptides — tripeptide-1, tripeptide-5 — have CAS numbers and PubChem entries that allow verification. This one did not resolve.
Does it work?
No efficacy literature isolating this ingredient was located, so there is nothing to evaluate.
Citations
1 sources- 1