CJC-1295 vs Sermorelin
Dosing, half-life, mechanism, benefits, and safety — side by side.
CJC-1295
ResearchLong-acting GHRH analog for sustained growth hormone elevation
Half-Life
~30 min (no DAC) / 6-8 days (DAC)
Route
SC
Dose
100-300 mcg (no DAC) / 2 mg (DAC) 1-2x/day (no DAC) or 1-2x/week (DAC)
MW
3647.19 Da
Sermorelin
ResearchGHRH analog stimulating natural growth hormone production
Half-Life
10-20 minutes
Route
SC
Dose
200-500 mcg Daily
MW
3357.88 Da
Quick Reference
| CJC-1295 | Sermorelin | |
|---|---|---|
| Category | N/A | N/A |
| Route | SC | SC |
| Typical Dose | 100-300 mcg (no DAC) / 2 mg (DAC) 1-2x/day (no DAC) or 1-2x/week (DAC) | 200-500 mcg Daily |
| Frequency | N/A | Daily |
| FDA Approved | No | No |
| WADA Status | Banned | Banned |
⏱ Pharmacokinetics
| CJC-1295 | Sermorelin | |
|---|---|---|
| Half-Life | ~30 min (no DAC) / 6-8 days (DAC) | 10-20 minutes |
| Research Status | Research compound - GHRH analog | FDA approved |
| CAS Number | 863288-34-0 | 86168-78-7 |
Molecular
| CJC-1295 | Sermorelin | |
|---|---|---|
| Molecular Weight | 3647.19 | 3357.88 |
| Molecular Formula | C165H269N47O46 | C149H246N44O42S |
| Sequence Length | 18 aa | 216 aa |
| Mechanism | GHRH analogue with extended half-life | GHRH analogue for pulsatile GH release |
Key Benefits
| CJC-1295 | Sermorelin | |
|---|---|---|
| Benefits | Fat loss support; Growth hormone boost; Lean muscle mass; Enhanced recovery; Improved sleep quality; Anti-aging effects; GH/IGF-1 Elevation: 2-10 fold GH increase for 6+ days; 45% IGF-1 increase; Extended Half-life: 5.8-8.1 days vs minutes for native GHRH | Natural GH stimulation; Improved sleep; Recovery enhancement; Anti-aging effects; Body composition; FDA approved; Increases natural GH production; Improves sleep |
Safety & Warnings
| CJC-1295 | Sermorelin | |
|---|---|---|
| Safety Note | Research compound only. Limited human safety data available. | FDA approved for growth hormone deficiency. Well-established safety profile. |
| Side Effects | Injection site reactions; WADA Prohibited; Severe/Fatal side effect; Flushing; Water retention; Joint pain; Hunger increase; Rare dizziness or prolactin rise | Interaction; Interaction; Antibody formation; Dizziness, urticaria; Injection site reactions; Headache; Flushing; Generally well-tolerated |
| Athlete Warning | 🛑 WADA BANNED - Prohibited in competitive sports as growth hormone releasing agent | 🛑 WADA BANNED - Prohibited in competitive sports as growth hormone releasing agent |
Which should you choose?
CJC-1295 has a longer half-life (~~30 min (no DAC) / 6-8 days (DAC)) than Sermorelin (~10-20 minutes), which can mean less frequent dosing.
CJC-1295 vs Sermorelin — FAQ
Which has a longer half-life: CJC-1295 or Sermorelin?
CJC-1295 has a half-life of ~~30 min (no DAC) / 6-8 days (DAC) while Sermorelin has a half-life of ~10-20 minutes. A longer half-life generally means less frequent dosing and more stable levels.
Can I stack CJC-1295 and Sermorelin together?
Whether CJC-1295 and Sermorelin can be stacked depends on their mechanisms and receptor targets. Use the stack compatibility checker to analyze synergies and conflicts before combining any peptides.
Which is better: CJC-1295 or Sermorelin?
There is no universal "better" peptide — it depends on your goal. CJC-1295 is GHRH analogue with extended half-life. Sermorelin is GHRH analogue for pulsatile GH release. Choose based on your primary goal and research profile.
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